Karzoug was the last immortal Runelord of Greed, who ruled for many years over his city of Shalast; an integral part of the lost Iskari Empire of Iskandar.

Karzoug is believed to have been destroyed, along with his six fellow Runelords, during the catastrophic events of Skyfall.

Legend has it; Karzoug was a specialist in "Greed-Magic" (now called Transmutation) and was said to have been an extremely powerful wizard. During his reign, Karzoug fought several wars against his most hated rival; the Runelord Alaznist.

Like all his fellow Runelords, Karzoug had a loyal apprentice; Rorskan. His fate is also unknown.