Karzoug was the last immortal Runelord of Greed, who ruled for many years over his city of Shalast; an integral part of the lost Iskari Empire of Iskandar.

Karzoug is believed to have been destroyed, along with the other six Runelords during Skyfall. Karzoug was a specialist in "Greed-Magic" (now called Transmutation) and was said to have been a powerful arcane knight. Karzoug fought several wars against his fellow Runelord, Alaznist, who he vehemently hated.

Like all seven Runelords, Karzoug had a loyal apprentice; Rorskan. His fate is also unknown.